Award
National Cancer Institute 5R01CA279180-04
Dissecting the role and mechanism of EML4-ALK condensates in oncogenic signaling and tumor growth
Recipient
University of California, San Francisco
Award Amount
$670,214.00
Ceiling
$670,214.00
Awarded
April 07, 2026
Identifier
5R01CA279180-04
Award for research on the role and mechanism of EML4-ALK condensates in oncogenic signaling and tumor growth, funded by the National Cancer Institute. The project investigates novel oncogenic signaling mechanisms in ALK-driven lung cancer to develop targeted therapies.
Description
This project aims to understand the role of phase separation in ALK fusion oncogenic signaling, define the protein architecture of ALK fusion protein granules, and identify key proteins involved. The goal is to develop mechanism-based therapeutic strategies to interfere with ALK protein granule assembly. The project focuses on the characterization of a new mechanism of oncogenic signaling involving biomolecular condensates in ALK-driven lung cancer and aims to develop molecular treatments that better control this cancer through improved precision medicine strategies.