Award
National Institute of General Medical Sciences 5R01GM074701-20
Interplay Between Chromatin and Co-Activator Complexes
Recipient
University of California Los Angeles
Award Amount
$371,280.00
Ceiling
$371,280.00
Awarded
April 01, 2025
Identifier
5R01GM074701-20
Research project awarded to University of California Los Angeles to study enhancer-promoter communication mechanisms in mouse embryonic stem cells, leveraging novel systems and advanced genomic techniques.
Description
The project focuses on understanding the physical and functional mechanisms of enhancer-promoter communication using advanced techniques like ChIP-seq, RNA-seq, and Promoter-Capture Hi-C. It investigates the role of ESRRB, Cohesin, TAF12, and other factors to clarify whether physical looping enables functional communication.