NIH Reporter #1K23DK149057-01

Mechanisms of sarcopenia in childhood chronic liver disease: Muscle mitochondrial dysfunction and protein catabolism

Research project focused on understanding the mechanisms of sarcopenia in children with chronic liver disease by studying muscle mitochondrial dysfunction and protein catabolism to inform future treatments.

Description

This project aims to investigate mitochondrial dysfunction, oxidative stress, imbalances in protein metabolism, and bile acid perturbations in skeletal muscle to define relationships between these processes and sarcopenia in children with chronic cholestasis. The findings will fill critical gaps in knowledge needed to inform future therapeutic interventions to improve outcomes for children with cholestatic liver disease.

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