Award
National Institute on Aging 1R01AG098800-01
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
Recipient
Florida Institute of Human/Machine Cognition
Award Amount
$1,827,526.00
Ceiling
$1,827,526.00
Awarded
July 08, 2026
Identifier
1R01AG098800-01
This NIH-funded research project investigates whether nitrate supplementation combined with exercise can improve health outcomes in older adults by enhancing cardiorespiratory fitness and muscle quality, and explores underlying biological mechanisms.
Description
Aging-related functional declines are caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments, reducing intrinsic capacity and healthspan. Exercise is a promising multipotent treatment, but individual responses vary significantly. This project aims to enhance exercise responsiveness in older adults by combining endurance and resistance training with nitrate-enriched dietary supplements to improve cellular, tissue, and systemic health benefits.