Award
National Institute of Allergy and Infectious Diseases 5R01AI188364-02
Foxp3 isoform expression and regulation of autoantibody production
Recipient
Benaroya Research Institute at Virginia Mason, Seattle, WA, United States
Award Amount
$730,946.00
Ceiling
$730,946.00
Awarded
December 05, 2025
Identifier
5R01AI188364-02
This award funds a multi-year research project investigating the role of Foxp3 isoforms in regulatory T cells and their contribution to autoimmune disease mechanisms, particularly SLE. The project includes animal model studies and patient cohort analysis to identify novel therapeutic pathways.
Description
Research project focused on the role of Foxp3 isoform expression in regulatory T cells and its impact on autoantibody production related to Systemic Lupus Erythematosus (SLE). The study aims to understand Treg dysfunction and loss of tolerance through the expression of the ∆E2 isoform of FOXP3, using animal models and patient cohort analysis.