# NIH Reporter #5R35GM157320-02

How cell maturation is regulated by circadian and metabolic rhythms

**Recipient:** University of Pennsylvania

**Award Amount:** $406,250.00
**Ceiling:** $406,250.00

**Awarded:** April 29, 2026

**Identifier:** 5R35GM157320-02

The project studies how circadian clock factors and feeding shape cell maturation and sustain mature cellular functions, using human in vitro and mouse in vivo models. The research may inform understanding of disease diagnosis and treatment.

### Description

Research project investigating how circadian and metabolic rhythms regulate the maturation and maintenance of specialized functions in pancreatic islet β cells and liver hepatocytes.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11352528)