Award
National Heart, Lung, and Blood Institute 5K08HL166950-03
Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension
Recipient
University of California, San Diego
Award Amount
$174,096.00
Ceiling
$174,096.00
Awarded
February 19, 2026
Identifier
5K08HL166950-03
Research project funded by NHLBI to investigate the role of LOX-derived eicosanoids in pulmonary arterial hypertension using various experimental models and techniques.
Description
This project aims to study upstream mediators of endothelial dysfunction related to disease risk and progression, focusing on bioactive lipid mediators called eicosanoids, particularly those derived from lipoxygenase (LOX) pathways. The research will utilize mass spectrometry, human biosamples, animal models, and cell culture experiments to elucidate the role of LOX-eicosanoids in PAH.