Award
National Heart, Lung, and Blood Institute 5R01HL166512-04
Preserving bone marrow niche integrity and function to rejuvenate aged hematopoietic stem cells
Recipient
University of Florida, Gainesville, FL, United States
Award Amount
$618,310.00
Ceiling
$618,310.00
Awarded
May 19, 2026
Identifier
5R01HL166512-04
NIH-funded research project to rejuvenate aged hematopoietic stem cells by enhancing NTN1 signaling to restore blood system function and improve health span.
Description
The project aims to test whether enhancing the NTN1 signaling pathway can restore the functional capacity of the aging blood system, focusing on rejuvenating aged hematopoietic stem cells (HSCs) and their niches. The study will elucidate cellular and molecular mechanisms by which aging of the bone marrow (BM) niche contributes to HSC decline, and validate Netrin-1 (NTN1) as a therapeutic target to improve hematopoietic health span and longevity.