Award
NIH Reporter #5U01CA282114-03
Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$1,015,368.00
Ceiling
$1,015,368.00
Awarded
September 11, 2025
Identifier
5U01CA282114-03
This award funds research to identify genes that regulate tumor microenvironment and cancer immunity using spatial functional genomics and computational analysis, aiming to improve cancer treatment outcomes.
Description
The project aims to determine genes regulating tumor composition, growth, and resistance to immunotherapy, focusing on four deadly cancers: NSCLC, PDAC, HGSOC, and OSCC. Utilizing large-scale genomic and transcriptomic data, spatial functional genomics, and computational analysis, the project employs a novel platform called Perturb-map to analyze gene functions at single-cell resolution with spatial architecture preserved. The study will investigate genes involved in tumor growth, morphology, metastasis, cell interactions, immune/stroma recruitment, and resistance to therapy, in immunocompetent orthotopic models.