Award
NIH Reporter #5R01DK126728-05
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Recipient
University of Minnesota
Award Amount
$639,978.00
Ceiling
$639,978.00
Awarded
December 18, 2024
Identifier
5R01DK126728-05
A research project funded by NIDDK to evaluate long-term islet graft function and its effects on glycemic control and diabetes complications in patients post-TPIAT, potentially impacting clinical practices and insurance coverage.
Description
This project studies the long-term function of islet grafts and their impact on glycemic control and diabetes complications in patients 5-20 years after total pancreatectomy with islet autotransplant (TPIAT). The study aims to determine the proportion of patients maintaining islet function, the association of islet function with glycemic control and diabetes complications, and mechanisms impacting glycemic control such as incretin hormone axis and alpha cell function. The research could influence clinical care and insurance coverage decisions for IAT.