Award
Emory University 11455021
Signal transduction mechanisms used by a group of uncharacterized ITAM-containing receptors in jawless vertebrates
Recipient
Emory University
Award Amount
$233,444.00
Ceiling
$233,444.00
Awarded
July 01, 2026
Identifier
11455021
Research project awarded to Emory University to study ITAM-containing receptors in jawless vertebrates, focusing on immune receptor signaling and potential immunotherapy applications.
Description
The project involves analyzing novel ITAMs from jawless vertebrates, specifically lampreys, to understand their role in immune receptor signaling and potential applications in immunotherapy. The project aims to identify which lamprey ITAMs can activate human T cells and to characterize the proteins associated with these receptors in lamprey leukocytes. The work will expand the understanding of immune receptor biology and could lead to the development of new therapeutic immune receptors.