Award
National Cancer Institute 4R01CA280833-04
Unlocking the Chemical Space of Cancer-Associated Perturbations
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$863,577.00
Ceiling
$863,577.00
Awarded
August 25, 2025
Identifier
4R01CA280833-04
The project develops the PEAR platform to profile tumor proteomes and identify therapeutic targets in cancer, advancing precision oncology through chemical biology.
Description
This project aims to develop the Probe Enabled Activity Reporting (PEAR) platform to profile tumor proteomes using chemical biology approaches. The goal is to understand proteomic changes in cancer cells in response to therapeutics, identify therapeutic targets, and advance precision oncology. The platform will visualize reactive targets, identify treatment-induced reactive targets, and elucidate tumor cell biology.