Award
National Institute of Allergy and Infectious Diseases 1K99AI197383-01
Investigating the epigenetic basis of monocyte exhaustion memory following sepsis
Recipient
Virginia Polytechnic Institute and State University, Blacksburg, VA
Award Amount
$112,256.00
Ceiling
$112,256.00
Awarded
April 24, 2026
Identifier
1K99AI197383-01
A research project funded by NIAID to study the epigenetic mechanisms of monocyte exhaustion after sepsis, with goals to identify therapeutic targets and understand immune memory effects.
Description
This project aims to profile the transcriptional and epigenetic features of monocyte exhaustion, investigate the role of DNA methylation and demethylation enzymes, and identify novel therapeutic targets related to sepsis-associated immune dysregulation.