Award
NIH Reporter #11368300
Mechanism of I- transport by the Na+/I- symporter (NIS)
Recipient
Vanderbilt University
Award Amount
$610,950.00
Ceiling
$610,950.00
Awarded
May 20, 2026
Identifier
11368300
NIH research grant awarded to Vanderbilt University to study the mechanism of iodide transport by the Na+/I- symporter, with potential applications in thyroid cancer therapy.
Description
This project aims to study the sodium/iodide symporter (NIS), a key protein involved in iodine transport into the thyroid gland, which is crucial for thyroid hormone synthesis. The research involves structural and mechanistic analysis of NIS, including cryo-EM structures of different conformations, and engineering mutants for potential cancer therapy applications.