Award
National Institute of Diabetes and Digestive and Kidney Diseases 1F31DK145094-01A1
Elucidating the real-time search dynamics of a transcription factor at its sole target
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$49,538.00
Ceiling
$49,538.00
Awarded
February 13, 2026
Identifier
1F31DK145094-01A1
Research project funded by NIDDK to study transcription factor dynamics and binding specificity using live-cell imaging techniques.
Description
This project aims to elucidate the mechanisms of transcription factor target-search dynamics and binding specificity, focusing on Zinc Finger Protein 410 targeting the Chd4 gene in erythroid cells. Using live-cell single-molecule tracking, the study will quantify search dynamics at the endogenous locus following structural and chromatin perturbations, providing insights into transcription factor function and chromatin biology.