Award
National Heart, Lung, and Blood Institute 5R01HL161070-05
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Recipient
University of Wisconsin-Madison
Award Amount
$388,750.00
Ceiling
$388,750.00
Awarded
February 06, 2026
Identifier
5R01HL161070-05
This NIH grant supports research on the mechanisms of calcium-induced arrhythmias in ARVC, focusing on the role of RyR2 phosphorylation and potential therapeutic interventions.
Description
Research grant focused on elucidating the mechanisms of arrhythmia in PKP2 deficiency, specifically investigating calcium mishandling and the role of the ryanodine receptor (RyR2) in arrhythmogenic right ventricular cardiomyopathy (ARVC). The project aims to test the effects of RyR2 phosphorylation inhibition and pharmacological modulation to prevent arrhythmias and improve patient survival.