Award
National Institute of Allergy and Infectious Diseases 1R21AI190535-01A1
Overcoming innate drug efflux systems to expand anthelmintic vulnerability
Recipient
Iowa State University, Ames, IA, United States
Award Amount
$453,063.00
Ceiling
$453,063.00
Awarded
February 13, 2026
Identifier
1R21AI190535-01A1
This award funds research to understand and inhibit drug efflux transporters in nematodes to improve the effectiveness of antiparasitic drugs.
Description
The project aims to investigate ATP-binding cassette transporters that remove antiparasitic drugs from nematode cells. Inhibition of P-glycoproteins will restore efficacy for existing anthelmintic drugs, contributing to the NIH mission of protecting the public from parasitic infectious diseases.