Award
National Institute of Neurological Disorders and Stroke 5R01NS122165-05
Uncover the role of H3.3-G343R mutation in shaping the DNA damage response, anti-tumor immunity and mechanisms of resistance in glioma.
Recipient
University of Michigan at Ann Arbor
Award Amount
$505,859.00
Ceiling
$505,859.00
Awarded
February 20, 2026
Identifier
5R01NS122165-05
Research project studying the impact of H3.3-G34R mutation in pediatric high-grade gliomas, focusing on tumor biology, immune response, and therapy resistance to develop targeted treatments.
Description
This project aims to study a subtype of pediatric high-grade gliomas harboring H3.3-G34R, ATRX, and TP53 mutations. The research focuses on understanding how H3.3-G34R impacts tumor biology, immune microenvironment, and response to therapies, including radiotherapy and DNA damage response inhibitors. The study involves creating genetically engineered mouse models to investigate epigenetic landscape alterations, chromatin states, DNA repair, genomic stability, and immune activation. The goal is to identify mechanisms of therapeutic resistance and develop tailored treatment strategies combining cell cycle or DDR inhibitors with radiotherapy.