Award
National Institute of Allergy and Infectious Diseases 1R01AI179901-01A1
Human Airway Macrophage Immunity in Tuberculosis: Defining Early Determinants of Infection
Recipient
University of Minnesota
Award Amount
$757,038.00
Ceiling
$757,038.00
Awarded
March 27, 2026
Identifier
1R01AI179901-01A1
Research project funded by NIAID to study early immune responses in airway macrophages to tuberculosis infection, aiming to identify factors influencing infection outcomes and improve preventive strategies.
Description
This project aims to understand why some people get infected after exposure to Mycobacterium tuberculosis while others do not, focusing on the role of human airway macrophages and their innate immune responses. The study involves recruiting volunteers and TB close contacts for bronchoalveolar lavage collection and uses scRNA-seq and ATAC-seq techniques to analyze transcriptomic and epigenetic landscapes.