Award
National Institute of Neurological Disorders and Stroke 5R01NS041435-24
Mechanisms by which effector T cells modulate endogenous remyelination
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$442,217.00
Ceiling
$442,217.00
Awarded
December 18, 2024
Identifier
5R01NS041435-24
Research grant to study how effector T cells influence remyelination in multiple sclerosis by targeting OPCs and developing NFkB pathway therapies.
Description
The project addresses multiple sclerosis (MS), focusing on the failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate neurons in an inflammatory environment. The research aims to characterize inflamed OPCs (iOPCs), understand their role in activating CD8 T cells, and develop therapies targeting the NFkB signaling pathway, including drugs like exenatide.