Award
National Cancer Institute 3R37CA289040-03S1
Elucidating The Adaptive Role Of Serine Codons During Pancreatic Tumorigenesis
Recipient
New York University School of Medicine
Award Amount
$103,192.00
Ceiling
$103,192.00
Awarded
April 07, 2026
Identifier
3R37CA289040-03S1
NIH/NCI awarded $103,192 to New York University School of Medicine for research on the role of serine codons in pancreatic cancer adaptation and tumorigenesis, focusing on mRNA translation efficiency under serine starvation conditions.
Description
This research project funded by the National Cancer Institute (NCI), part of NIH, aims to decipher signaling cascades and mechanisms that regulate mRNA translation efficiencies of Ser codons during Ser-starvation and target these pathways during pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. The findings will enhance understanding of mRNA translation efficiency regulation, identify therapeutic vulnerabilities, and potentially shift perceptions of codon regulatory pathways in human health and disease.