# NIH Reporter #5P01CA275717-03

Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis

**Recipient:** University of Texas Health Science Center

**Award Amount:** $527,548.00
**Ceiling:** $527,548.00

**Awarded:** September 08, 2026

**Identifier:** 5P01CA275717-03

NIH grant awarded to University of Texas Health Science Center for research on DNA repair mechanisms involving BRCA1 and 53BP1, aiming to improve targeted cancer therapies.

### Description

This NIH grant supports research on DNA repair mechanisms related to cancer therapy, focusing on the regulation of DNA end resection by the 53BP1 axis and associated proteins. The project aims to delineate novel mechanisms by which the opposing actions of 53BP1-CTC1-STN1-TEN1 (CST) and BRCA1-BARD1 regulate the activities of the long-range resection enzymes EXO1 and BLM-DNA2, shedding light on the mechanistic principles of DNA double strand break repair pathway choice and guiding targeted cancer therapies for HDR-deficient cancers.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11385451)