NIH Reporter #1R01DA062741-01A1

Delineating developmental windows of vulnerability for cannabis exposure and assessing for causal relations between cannabis use, neurodevelopment, and behavior

A research project funded by NIH to study the impact of cannabis use on neurodevelopment and behavior across different developmental stages using large neuroimaging datasets, aiming to identify vulnerable periods and causal relationships.

Description

This study aims to advance the understanding of how cannabis use at various stages of development, in combination with specific genetic and environmental factors, influences neurodevelopmental and behavioral outcomes. Leveraging three existing datasets (ABCD, IMAGEN, ENIGMA-Addiction), the objective is to identify developmental windows in which the brain and/or specific brain regions are most vulnerable to cannabis, employ causal inference methods to assess evidence for causal relations between cannabis, neurodevelopment, and behavior, and characterize moderating factors that contribute to individual variability with respect to cannabis-related outcomes.

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