Award
National Cancer Institute 5R01CA257523-05
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.
Recipient
Massachusetts General Hospital
Award Amount
$904,596.00
Ceiling
$904,596.00
Awarded
May 13, 2025
Identifier
5R01CA257523-05
A research project funded by the National Cancer Institute to study how aging-related inflammation affects intestinal cells and the effectiveness of aspirin in preventing colorectal cancer, with the goal of improving prevention guidelines and biomarkers.
Description
This project investigates the impact of low-dose aspirin (LDA) on colorectal cancer risk in older adults, focusing on the role of inflammaging on intestinal stem cells and aspirin chemoprevention. It aims to examine LDA's effects at single cell resolution on colonic epithelium, patient-derived organoids, and urinary prostaglandins in a randomized controlled trial and experimental models, to inform clinical guidelines and biomarker development.