Award
National Heart, Lung, and Blood Institute 5R01HL175555-03
Targeting dysfunctional epithelial repair in pulmonary fibrosis
Recipient
University of Michigan at Ann Arbor
Award Amount
$637,999.00
Ceiling
$637,999.00
Awarded
July 15, 2026
Identifier
5R01HL175555-03
A research grant awarded to the University of Michigan at Ann Arbor to study dysfunctional epithelial repair in pulmonary fibrosis, focusing on HIF signaling pathways to develop new therapeutic strategies for IPF.
Description
This research grant focuses on studying signaling pathways, including Hypoxia Inducible Factor (HIF), that inhibit normal repair mechanisms in the lung after injury, aiming to improve healing and prevent or limit fibrosis in Idiopathic Pulmonary Fibrosis (IPF). The project involves identifying factors driving dysfunctional epithelial states, determining the impact of HIF signaling on alveolar repair, and investigating niche-specific mechanisms regulating fibrosis.