Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD117756-02
Immune regulation of arenavirus infections in the placenta
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$645,296.00
Ceiling
$645,296.00
Awarded
March 26, 2026
Identifier
5R01HD117756-02
Research project funded by NICHD to study arenavirus infections in the placenta and their effects on pregnancy outcomes using human placenta models and guinea pig experiments.
Description
The project investigates how arenavirus infections during pregnancy cause adverse outcomes, focusing on the role of the placenta and decidua as reservoirs for viral replication and the immune response's impact on placental function. Using in vitro models of human placenta and guinea pig experiments, the study aims to elucidate mechanisms of placental infection and dysfunction caused by viruses such as PICV, JUNV, and LASV.