Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R03AR084261-01A1
Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets
Recipient
CITY COLLEGE OF NEW YORK
Award Amount
$159,594.00
Ceiling
$159,594.00
Awarded
September 25, 2024
Identifier
1R03AR084261-01A1
NIH grant awarded to investigate the cellular and extracellular consequences of TMEM38B mutation in osteogenesis imperfecta to identify new therapeutic targets.
Description
The project aims to clarify the effect of mutant TRIC-B in osteoblast function and bone fragility. It involves generating an osteoblast-specific TRIC-B knockout mouse and includes advanced molecular, biochemical, and high-resolution imaging techniques.