Award
National Cancer Institute 5R01CA249667-05
Tyrosine phosphorylation of p27Kip1 as a biomarker to identify Cdk4/6 inhibitor response
Recipient
SUNY Downstate Medical Center, Brooklyn, NY
Award Amount
$623,507.00
Ceiling
$623,507.00
Awarded
December 12, 2025
Identifier
5R01CA249667-05
The project aims to develop and validate a biomarker, p27Kip1 pY88, to identify metastatic breast cancer patients responsive to CDK4/6 inhibitor therapy, improving patient selection and expanding therapy use.
Description
This translational project focuses on the utility of a novel diagnostic marker, p27Kip1 pY88, to identify patients who would respond to the currently used CDK4i therapy. The goal is to demonstrate that p27 pY is a diagnostic biomarker to identify CDK4/6i-responsive patients and to understand mechanisms of resistance, further informing potential uses of the CDK4/6i drugs.