Award
National Institute of General Medical Sciences 5R35GM118097-10
Mechanism of Immune Dysfunction and Morbid Outcomes in Response to Shock/Sepsis
Recipient
Rhode Island Hospital
Award Amount
$562,793.00
Ceiling
$562,793.00
Awarded
June 05, 2025
Identifier
5R35GM118097-10
Research project funded by the National Institute of General Medical Sciences to study immune dysfunction and organ injury in sepsis, focusing on checkpoint proteins as potential therapeutic targets.
Description
This study aims to determine if a family of novel checkpoint proteins, expressed on immune and non-immune cells, can be used to block the development of organ injury in the critically ill patient. The project investigates the role of checkpoint proteins such as PD-1, BTLA, and VISTA in sepsis and organ injury, utilizing murine models and clinical studies to identify prognostic markers and therapeutic targets.