Award
National Institute on Drug Abuse 1R21DA061097-01
Molecular pharmacology of xylazine at adrenoceptors: Relation to necrotic skin lesions associated with chronic intravenous administration
Recipient
Mercer University Macon
Award Amount
$387,750.00
Ceiling
$387,750.00
Awarded
September 10, 2024
Identifier
1R21DA061097-01
This NIH grant awarded to Mercer University Macon supports research on the pharmacology of xylazine at adrenoceptors to understand its role in causing necrotic skin lesions from chronic intravenous use, investigating receptor mechanisms and signaling pathways.
Description
The project aims to elucidate the pharmacology of xylazine at adrenoceptors, focusing on its role in necrotic skin lesions linked to intravenous use. It involves assessing binding affinities, G protein signaling, and in vivo mechanisms of skin necrosis.