Award
National Institute of Neurological Disorders and Stroke 5R01NS141861-02
Inflammasomes - a driver of sexual dimorphism to glioma therapies
Recipient
Duke University, Durham, NC
Award Amount
$406,958.00
Ceiling
$406,958.00
Awarded
April 21, 2026
Identifier
5R01NS141861-02
Research project investigating the role of inflammasomes in sex-specific immune responses and therapy outcomes in glioma, focusing on NLRP3's influence on inflammation and treatment efficacy.
Description
This project aims to evaluate the role of inflammasomes, particularly NLRP3, in sex-specific immune responses and therapy outcomes in glioma. The study will investigate how NLRP3-induced inflammation influences immune suppression and treatment efficacy, focusing on sex-dependent differences.