Award
NIH Reporter #RFA-AI-21-030
Project 2. Immune evasion, trafficking, and nuclear import
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$818,299.00
Ceiling
$818,299.00
Awarded
July 27, 2026
Identifier
RFA-AI-21-030
This NIH grant awarded to the University of Pittsburgh supports research on HIV-1 capsid mechanisms related to immune evasion and nuclear import, aiming to inform capsid inhibitor development.
Description
The project focuses on the HIV-1 capsid's role in viral ingress and nuclear entry, including uncoating, host factor recognition, trafficking along microtubules, nuclear import, and genome integration. It aims to elucidate the interactions of HIV-1 capsid with host innate immune proteins (MxB, TRIM5α/TRIMCyp), intracellular trafficking proteins (kinesin-1/FEZ1, dynein/dynactin/BICD2), and host dependency factors involved in nuclear import (nucleoporins Nup358, Nup153, CPSF6, SUN1/2). The goal is to provide structural and dynamic insights to guide the development of capsid inhibitors.