Award
National Institute of General Medical Sciences 5R35GM147111-06
DNA ligase activities during base excision repair coordination
Recipient
University of Nebraska Medical Center, Omaha, NE, United States
Award Amount
$381,878.00
Ceiling
$381,878.00
Awarded
May 13, 2026
Identifier
5R35GM147111-06
Award for research on DNA ligase activities during base excision repair coordination to understand molecular mechanisms and structural basis of DNA repair, aiming to elucidate repair fidelity and implications for genome stability and disease.
Description
This project investigates the molecular and structural basis of DNA repair mechanisms, with implications for understanding genome stability and cancer. The research focuses on molecular mechanisms of DNA repair proteins during base excision repair (BER), structural analysis of DNA ligase and substrate interactions, and structural architecture of BER multi-protein complexes.