Award
National Heart, Lung, and Blood Institute 5R01HL165172-03
Transfer RNAs in Hematopoietic Stem Cell Function
Recipient
University of California, San Diego
Award Amount
$316,000.00
Ceiling
$316,000.00
Awarded
July 21, 2025
Identifier
5R01HL165172-03
A multi-year NIH grant awarded to University of California, San Diego to study the role of transfer RNAs in regulating hematopoietic stem cell maintenance and function, with implications for blood disorders.
Description
This project investigates the impact of tRNA mutations on hematopoietic stem cell function, utilizing chromatin immunoprecipitation, sequencing, flow cytometry, ribosome profiling, and RNA-sequencing techniques. The research aims to understand if mutations in tRNAs impair blood stem cell function, which could inform treatments for blood disorders.