Award
National Cancer Institute 5R01CA275182-04
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment
Recipient
University of Michigan at Ann Arbor
Award Amount
$613,208.00
Ceiling
$613,208.00
Awarded
May 18, 2026
Identifier
5R01CA275182-04
This NIH-funded project investigates GLI transcription factors in pancreatic cancer microenvironment to understand tumor progression and develop therapies.
Description
The project aims to investigate the role of GLI proteins, effectors of the Hedgehog signaling pathway, in pancreatic cancer progression. The research will involve genetic approaches, in vivo mouse models, and analysis of fibroblast-immune crosstalk to identify GLI transcriptional targets and understand their impact on tumor microenvironment and therapy.