Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK136904-03
A Pilot Study to Evaluate the Anabolic Effect of Testosterone on Muscles of the Pelvic Floor in Older Women with Stress Urinary Incontinence
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$354,840.00
Ceiling
$354,840.00
Awarded
July 03, 2025
Identifier
5R01DK136904-03
This award funds a clinical trial to evaluate testosterone therapy's effect on pelvic floor muscles and urinary function in older women with stress urinary incontinence, aiming to improve quality of life.
Description
A randomized, double-blind, placebo-controlled trial in older postmenopausal women to assess whether testosterone therapy can increase pelvic floor muscles and improve urinary function in women aged 60+ with stress urinary incontinence (SUI). The study involves MRI, urodynamic studies, and assessment of urinary symptoms and quality of life. The intervention is a 12-week testosterone supplementation trial aiming to provide a safe, effective, and potentially transformative treatment for women with SUI.