Award
National Institute of General Medical Sciences 5R35GM149337-03
A translational approach to predicting small molecule drug permeation through microneedle-treated skin
Recipient
University of Iowa, Iowa City, IA, United States
Award Amount
$399,104.00
Ceiling
$399,104.00
Awarded
July 18, 2025
Identifier
5R35GM149337-03
Research project funded by NIGMS to study drug permeation through microneedle-treated skin using lab, animal, and human studies to improve drug delivery methods.
Description
This MIRA research program studies how chemical properties of drug compounds affect their absorption through skin treated with microneedles. It involves laboratory experiments, animal studies, and human trials to identify key factors influencing drug permeation and to develop improved drug delivery methods. The project aims to understand structure-permeability relationships and biological factors affecting API permeability with microneedles, focusing on properties like ionization, logP, and pKa, and examining effects of temperature and microneedle characteristics.