Award
NIH Reporter #5R37CA241486-07
Molecular mechanisms underlying lineage plasticity in prostate cancer
Recipient
DANA-FARBER CANCER INST
Award Amount
$601,022.00
Ceiling
$601,022.00
Awarded
May 25, 2026
Identifier
5R37CA241486-07
The award supports research on the molecular mechanisms of lineage plasticity in prostate cancer, particularly the role of Notch signaling and lineage-determining transcription factors, to develop new therapeutic approaches for treatment-resistant prostate cancer.
Description
This project aims to investigate the molecular mechanisms driving lineage plasticity in prostate cancer, focusing on the role of Notch signaling and transcription factors such as ASCL1 and INSM1. The goal is to identify new therapeutic targets to improve early detection and treatment of treatment-resistant prostate cancer.