Award
National Institute of General Medical Sciences 1R35GM158123-01
Thermodynamic and Functional Analysis of Consensus and Covariance in Proteins, and Bivalent Notch Complexes
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$65,963.00
Ceiling
$65,963.00
Awarded
August 25, 2025
Identifier
1R35GM158123-01
Research grant to study protein stability, function, and Notch signaling using AI and sequence databases to aid therapeutic design and understand disease mechanisms.
Description
The proposed research aims to improve understanding of sequence features that determine protein stability and function, aiding in the design of therapeutics and diagnostics. It also investigates mechanisms underlying Notch signaling in humans and disease mutations affecting complex assembly.