Award
NIH Reporter #1R43DK145380-01
Phagineering the gut microbiome: Bacteriophages to reduce Desulfovibrio spp. and hydrogen sulfide in the intestine
Recipient
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Award Amount
$178,026.00
Ceiling
$178,026.00
Awarded
September 05, 2025
Identifier
1R43DK145380-01
Research project to develop bacteriophage cocktails targeting Desulfovibrio bacteria in the gut to reduce hydrogen sulfide and improve gut health.
Description
The proposed research aims to develop a novel prebiotic bacteriophage cocktail to target Desulfovibrio spp. in the human gut, reducing hydrogen sulfide (H2S) production associated with malodorous flatulence and certain health conditions. The project involves assembling a panel of Desulfovibrio isolates, performing phage hunts, characterizing isolated phages, formulating cocktails, and expanding host range through directed evolution. The project is led by Dr. Justin Boeckman, with mentorship from Dr. Jason Gill and Dr. Neema Mayhugh.