Award
National Institute of Mental Health 5R01MH128868-06
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Recipient
Florida International University, Miami, FL, United States
Award Amount
$1,007,048.00
Ceiling
$1,007,048.00
Awarded
September 16, 2025
Identifier
5R01MH128868-06
A clinical research project studying the effects of CBT-AD on the microbiome-gut-brain axis in depressed HIV-positive individuals to improve mental health and immune regulation.
Description
This randomized controlled trial will be the first to examine the efficacy of an evidence-based Cognitive-Behavioral Therapy for Adherence and Depression (CBT-AD) treatment for altering microbiome-gut-brain (MGB) axis pathways in depressed people with HIV (PWH) receiving effective anti-retroviral therapy. Leveraging an evidence-based CBT-AD treatment as an experimental probe will advance our basic understanding of the MGB axis pathways whereby decreasing depression potentiates alterations in key neurobehavioral substates relevant to depression in PWH. Examining MGB axis moderators and mediators using multi-level, high dimensional data will support efforts to identify subgroups of individuals who may be most responsive to CBT-AD as well as inform the development of a new generation of pharmacologic and behavioral treatments for depression targeting the MGB axis in PWH.