Award
National Human Genome Research Institute 1K99HG014240-01
Functional Mapping of Translation Initiation Kinetics to Quantify the Protein-Coding Capacity of the Human Genome
Recipient
Massachusetts Institute of Technology
Award Amount
$133,332.00
Ceiling
$133,332.00
Awarded
August 18, 2025
Identifier
1K99HG014240-01
Development of a functional genomics platform to study translation initiation kinetics in human cells, with implications for disease research.
Description
This project aims to develop a functional genomics platform, termed MIT-seq, to measure translation initiation kinetics across the human transcriptome. The research will explore variations in initiation kinetics between different cell types, such as kidney cells and neurons, and examine dysregulation in diseases like Fragile X Syndrome.