Award
National Institute on Aging 1R01AG097580-01
Real-world evidence to clarify risk-benefit of antihypertensive intensification vs. de-escalation and blood pressure thresholds to minimize harms and maximize brain and heart health in older adults
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$660,505.00
Ceiling
$660,505.00
Awarded
July 17, 2026
Identifier
1R01AG097580-01
The award funds research to optimize blood pressure treatment strategies in older adults by using real-world data and advanced analytics to balance benefits and risks, addressing gaps in clinical trial representation.
Description
This project aims to generate real-world evidence to determine when to intensify or de-escalate antihypertensive therapy in older adults, considering factors like age, frailty, comorbidities, and APOE ε4 status. It leverages large datasets and employs causal inference methods and natural language processing to improve individualized care and optimize blood pressure management, balancing benefits and harms.