Award
National Institute of General Medical Sciences 5R35GM134962-07
Structure and Mechanism of G-proteins and cell adhesion proteins in regulation of cell growth and motility
Recipient
University of North Carolina Chapel Hill
Award Amount
$602,153.00
Ceiling
$602,153.00
Awarded
January 14, 2026
Identifier
5R35GM134962-07
This award supports research on the mechanisms of G-proteins and cell adhesion proteins in cell growth and motility, aiming to understand their roles in disease and develop targeted therapies.
Description
The project involves multidisciplinary studies on G-proteins and cell adhesion proteins, focusing on mechanisms governing their activation, signaling, and roles in cell morphology, motility, and disease. It aims to elucidate allosteric networks, regulation by pH, and the impact of metavinculin mutations, employing computational, structural, biochemical, and cell biology approaches.