Award
NIH Reporter #7R01HL163820-04
A redox-sensitive switch in the macrophage nucleus regulates acute phase inflammatory injury
Recipient
H. Lee Moffitt Cancer Center & Research Institute
Award Amount
$613,814.00
Ceiling
$613,814.00
Awarded
July 23, 2025
Identifier
7R01HL163820-04
NIH grant awarded to study how reactive oxygen species in macrophage nuclei regulate inflammation and ARDS risk, aiming to develop targeted therapies.
Description
This project aims to investigate the role of reactive oxygen species (ROS) produced in the nucleus of macrophages in regulating inflammation and the transition to resolution, with implications for preventing Acute Respiratory Distress Syndrome (ARDS). The study hypothesizes that oxidative stress in the nucleus mimics nitric oxide (NO) effects, extending inflammation and increasing ARDS risk, especially in vulnerable populations such as the elderly, smokers, and those with metabolic conditions.