Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK135804-03
Prescription exercise for Older men with Urinary Disease (PROUD) pilot study
Recipient
NORTHERN CALIFORNIA INSTITUTE/RES/EDU, SAN FRANCISCO, CA, UNITED STATES
Award Amount
$350,886.00
Ceiling
$350,886.00
Awarded
May 07, 2025
Identifier
5R01DK135804-03
This award funds a pilot study to test a remote exercise intervention for older men with urinary disease, focusing on feasibility, safety, and mechanistic outcomes.
Description
The project aims to evaluate the feasibility, acceptability, fidelity, and safety of a remote exercise intervention among 68 physically inactive older men with lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). The intervention includes personalized aerobic and resistance exercises supported by weekly coaching, biofeedback, and minimal equipment. The study will assess changes in LUTS, urologic and physical function, actigraphy measures, and mechanistic biomarkers such as muscle mass, mitochondrial function, and urine α1-microglobulin.