Award
NIH Reporter #5R35GM128855-09
Spindle Assembly Checkpoint Silencing
Recipient
University of North Carolina Chapel Hill, Department of Pharmacology
Award Amount
$454,118.00
Ceiling
$454,118.00
Awarded
July 24, 2026
Identifier
5R35GM128855-09
Research grant awarded to study the regulation of APC/C in mitosis and its role in cell cycle control and cancer, using advanced structural biology techniques.
Description
The project aims to understand the regulation of the Anaphase-Promoting Complex/Cyclosome (APC/C) during mitosis, focusing on its role in cell cycle control and its implications in cancer. Using advanced techniques such as cryo-EM and mass photometry, the research will explore how APC/C interacts with various proteins and chromatin to coordinate gene expression and protein degradation.