Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK142678-01A1
The molecular and physiologic effects of calcineurin inhibitors on WNK body bimolecular condensates
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$769,882.00
Ceiling
$769,882.00
Awarded
April 17, 2026
Identifier
1R01DK142678-01A1
NIH awarded a research grant to study how calcineurin inhibitors affect WNK body biomolecular condensates, aiming to understand and mitigate side effects in organ transplant patients.
Description
This NIH research project grant investigates the role of WNK biomolecular condensates in mediating side effects of calcineurin inhibitors like tacrolimus, used to prevent transplant rejection but causing adverse effects such as hypertension, hyperkalemia, and metabolic acidosis. The study involves cellular models, mouse models, and human kidney biopsies to validate WNK bodies as pharmacological targets and understand their role in kidney physiology.