Award
National Institute of Mental Health 5R01MH121620-05
1/3-Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-life Depression (Rembrandt)
Recipient
Vanderbilt University Medical Center, Nashville, TN, United States
Award Amount
$800,438.00
Ceiling
$800,438.00
Awarded
November 29, 2023
Identifier
5R01MH121620-05
This NIH-funded project studies neurobiological factors predicting recurrence risk in late-life depression through longitudinal assessments, aiming to improve early detection and intervention.
Description
A three-site, two-year longitudinal study of remitted late-life depression (LLD) and never-depressed elders, with assessments every 8 months including clinical, cognitive, neuroimaging, and ecological momentary assessments (EMA) of mood variability, stress exposure, cognitive performance, and passive actigraphy. The study aims to identify neurobiological factors predicting recurrence risk and examine how cognitive performance changes are influenced by these factors. The project also aims to develop easy-to-use platforms (e.g., apps) for early detection of recurrence risk in clinical practice.