Award
National Institute of Allergy and Infectious Diseases (NIAID) 5F31AI194729-02
Age-associated changes in B cell and antibody effector responses to Streptococcus pneumoniae
Recipient
Wake Forest University Health Sciences
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
June 25, 2026
Identifier
5F31AI194729-02
The project investigates how aging affects vaccine responses to Streptococcus pneumoniae, focusing on antibody responses and B cell populations, aiming to improve vaccine strategies for the elderly.
Description
This project proposes using an aged mouse model to elucidate cellular responses involved in immune response post-vaccination and to identify deficits in the anti-pneumococcal immune response in the aged environment. The work aims to support improved preventative measures and therapeutics against pneumococcal disease in the elderly.